Theoretical and Methodological Framework for the Development of Urban Climatic Planning Recommendation Maps

Urban climatic analyses and planning recommendation maps are becoming increasingly important in the climate-sensitive planning of cities. Urban climatic maps typically include two main components (Ren et al. 2012): an urban climatic analysis map and an urban climatic planning recommendation map. Given the urgent need for action due to climatic changes in urban areas, planning recommendation maps are essential for introducing and locating measures that effectively increase the adaptive capacity of cities, thus increasing the resilience of urban areas and their inhabitants (Baumüller 2015). The first urban climatic maps were produced in Germany in the 1970s and currently they are used worldwide. The aim of this contribution is to develop a theoretical and methodological framework for the development of urban climatic planning recommendation maps. The main focus is on the review of existing theories and methods that serves as a roadmap for developing these maps. The examples show that these analyses usually consist of four steps or four areas of processing: (i) an urban climatic analysis, (ii) additional in-depth analyses, (iii) the development and location of measures and (iv) the consolidation in a planning information map (Ren et al. 2011). Within the urban climatic analysis two main approaches are common: pure static GIS (Geographic Information System) derived maps or mainly meteorologically focused maps including the calculation of regional climate simulations (and hybrid forms thereof). Supplementary in-depth analyses are often carried out, such as the intersection with socio-demographic data to identify areas that are particularly vulnerable from a social point of view, or analyses based on specific urban or spatial configurations (Reisinger et al. 2020). In the third step of the process, measures are usually developed at different levels or for different sectors of urban development. As a final step, the results are summarised in planning recommendation maps and the measures are spatially located (Baumüller 2015). Each of these individual steps has been intensively researched in the last few years; the synopsis or bringing together of these numerous research projects and approaches is a gap that this contribution seeks to fill. The contribution demonstrates available approaches, methods and tools necessary to translate scientific climatic knowledge into urban planning recommendation maps, considering that the analyses for a particular city or municipality are strongly limited in reproducibility to other citys, even in the same country. Based on this, a theoretical and methodological framework for the development of urban climatic planning recommendation maps is elaborated that enables the creation of these

Comparison of a pediatric practice-based therapy and an interdisciplinary ambulatory treatment in social pediatric centers for migraine in children: a nation-wide randomized-controlled trial in Germany: \textquotedblmoma - modules on migraine activity\textquotedbl

BACKGROUND Migraine is common in childhood, peaks in adolescents and persists into adulthood in at least 40% of patients. There is need for early interventions to improve the burden of disease and, if possible, reduce chronification. The aim of the project is to compare two types of ambulatory treatment strategies regarding their effect on headache days and quality of life in 6 to 11 year old children with migraine: 1) the routine care in pediatricians' practices (intervention group A) and 2) a structured interdisciplinary multimodal intervention administered at social pediatric centers (intervention group B). METHODS The study is a nation-wide cluster-randomized study. Based on the postal codes the regions are randomly assigned to the two intervention-strategies. Children with migraine are recruited in the pediatric practices, as common outpatient-care in the German health-care system. Parents rate headache frequency, intensity and acute medication intake at a daily basis via a digital smartphone application specifically designed for the study. Migraine-related disability and quality of life are assessed every 3 months. Study duration is 9 months for every participant: 3 months of baseline at the pediatric practice (both groups); 3 months of intervention at the pediatric practice (intervention group A) or at the social pediatric center (intervention group B), respectively; 3 months of follow-up at the pediatric practice (both groups). DISCUSSION Results of the planned comparison of routine care in pediatric practices and interdisciplinary social pediatric centers will be relevant for treatment of children with migraine, both for the individual and for the health care system. TRIAL REGISTRATION The study was approved by the ethics committee at the Ludwig-Maximilians-University Munich (number 18-804) and was retrospectively registered on 27 April 2021 in the WHO approved German Clinical Trials Register (number DRKS00016698 )

Learning Lens Blur Fields

Optical blur is an inherent property of any lens system and is challenging to model in modern cameras because of their complex optical elements. To tackle this challenge, we introduce a high-dimensional neural representation of blur$-$$\textit{the lens blur field}$$-$and a practical method for acquiring it. The lens blur field is a multilayer perceptron (MLP) designed to (1) accurately capture variations of the lens 2D point spread function over image plane location, focus setting and, optionally, depth and (2) represent these variations parametrically as a single, sensor-specific function. The representation models the combined effects of defocus, diffraction, aberration, and accounts for sensor features such as pixel color filters and pixel-specific micro-lenses. To learn the real-world blur field of a given device, we formulate a generalized non-blind deconvolution problem that directly optimizes the MLP weights using a small set of focal stacks as the only input. We also provide a first-of-its-kind dataset of 5D blur fields$-$for smartphone cameras, camera bodies equipped with a variety of lenses, etc. Lastly, we show that acquired 5D blur fields are expressive and accurate enough to reveal, for the first time, differences in optical behavior of smartphone devices of the same make and model

Migraine and the development of additional psychiatric and pain disorders in the transition from adolescence to adulthood

Introduction: The transition from childhood to adolescence and from adolescence to adulthood are vulnerable phases in life. In these phases, late or insufficient treatment of diseases may lead to chronification and favor development of additional disorders. In adolescents, migraine often has a highly negative impact on school performance and everyday life. The hypothesis of the present study was that adolescents with migraine have a higher risk for developing additional disorders such as psychiatric disorders or other pain syndromes in the course of the disease. Materials and methods: In this study, we analyzed health insurance data of 56,597 German adolescents at the age of 15 years in the year 2006. By using the International Classification of Diseases (ICD 10), we determined a group with migraine diagnosis in the year 2006 and a control group without any headache diagnosis in 2006. We then compared both groups regarding the development of additional disorders (based on the ICD 10) during the following 10 years (2007 to 2016). Results: Adolescents with migraine had a 2.1 fold higher risk than persons without migraine diagnosis to develop an additional affective or mood disorder, a 1.8 fold higher risk to obtain neurotic, stress-related and somatoform disorders, a 1.8 fold higher risk to subsequently suffer from behavioral syndromes, a 1.6 higher risk to get back pain and a 1.5 fold higher risk for irritable bowel syndrome during the next 10 years. Conclusion: Adolescents with migraine are at risk for developing additional disorders later. Considering and addressing the patient’s risks and potential medical and psychosocial problems might improve the long-term outcome significantly

Migräne im Kindes- und Jugendalter — Ausblick auf innovative Behandlungsansätze im Rahmen multimodaler Therapiekonzepte

Although migraine is a~relevant health issue in children and adolescents, clinical care and research are still underrepresented and underfunded in this field. Quality of life can be significantly reduced when living with frequent episodes of pain. Due to the high level of vulnerability of the developing brain during adolescence, the risk of chronification and persistence into adulthood is high. In this narrative review, we describe the corner stones of a~patient-centered, multimodular treatment regimen. Further, an update on the pathophysiology of migraine is given considering the concept of a~periodically oscillating functional state of the brain in migraine patients (\textquotedblmigraine is a~brain state\textquotedbl). Besides central mechanisms, muscular structures with the symptoms of muscular pain, tenderness, or myofascial trigger points play an important role. Against this background, the currently available nonpharmacological and innovative neuromodulating approaches are presented focusing on the method of repetitive peripheral magnetic stimulation.Die Migräne ist auch im Kindes- und Jugendalter ein häufiges, aber in klinischer Versorgung und Wissenschaft oft unterrepräsentiertes Krankheitsbild. Gerade im Kindes- und Jugendalter bestehen relevante Einschränkungen der Lebensqualität durch das (häufige) Schmerzerfahren. Bedingt durch die entwicklungsspezifisch hohe Vulnerabilität des adoleszenten Gehirns besteht ein hohes Chronifizierungs- und Persistenzrisiko bis ins Erwachsenenalter hinein. In diesem Beitrag werden die Bestandteile eines patientenzentrierten, multimodalen Therapiekonzepts dargestellt. Darüber hinaus werden die aktuellsten Erkenntnisse zu den pathophysiologischen Grundlagen der Migräneerkrankung beleuchtet, nach denen Migräne durch einen sich phasenweise verändernden Funktionszustand des Gehirns entsteht (Stichwort: „migraine is a brain state“). Auch periphere Komponenten wie Muskelschmerzen, -verspannungen und -triggerpunkte spielen eine wichtige Rolle. Vor diesem Hintergrund werden nichtpharmakologische innovative Therapieansätze vorgestellt, die auf dem Prinzip der Neuromodulation beruhen, mit Fokus auf der repetitiven peripheren Magnetstimulation

Understanding metric-related pitfalls in image analysis validation

Validation metrics are key for the reliable tracking of scientific progress and for bridging the current chasm between artificial intelligence (AI) research and its translation into practice. However, increasing evidence shows that particularly in image analysis, metrics are often chosen inadequately in relation to the underlying research problem. This could be attributed to a lack of accessibility of metric-related knowledge: While taking into account the individual strengths, weaknesses, and limitations of validation metrics is a critical prerequisite to making educated choices, the relevant knowledge is currently scattered and poorly accessible to individual researchers. Based on a multi-stage Delphi process conducted by a multidisciplinary expert consortium as well as extensive community feedback, the present work provides the first reliable and comprehensive common point of access to information on pitfalls related to validation metrics in image analysis. Focusing on biomedical image analysis but with the potential of transfer to other fields, the addressed pitfalls generalize across application domains and are categorized according to a newly created, domain-agnostic taxonomy. To facilitate comprehension, illustrations and specific examples accompany each pitfall. As a structured body of information accessible to researchers of all levels of expertise, this work enhances global comprehension of a key topic in image analysis validation.Comment: Shared first authors: Annika Reinke, Minu D. Tizabi; shared senior authors: Paul F. J\"ager, Lena Maier-Hei

A Rederivation of the Spin-dependent Next-to-leading Order Splitting Functions

We perform a new calculation of the polarized next-to-leading order splitting functions, using the method developed by Curci, Furmanski and Petronzio. We confirm the results of the recent calculation by Mertig and van Neerven.Comment: 16 Pages, LaTeX, 2 figures as eps - files Eqs. (28),(29) in the previous version contained errors and have been correcte

Multi-view image fusion

We present an end-to-end learned system for fusing multiple misaligned photographs of the same scene into a chosen target view. We demonstrate three use cases: 1) color transfer for inferring color for a monochrome view, 2) HDR fusion for merging misaligned bracketed exposures, and 3) detail transfer for reprojecting a high definition image to the point of view of an affordable VR180-camera. While the system can be trained end-to-end, it consists of three distinct steps: feature extraction, image warping and fusion. We present a novel cascaded feature extraction method that enables us to synergetically learn optical flow at different resolution levels. We show that this significantly improves the network’s ability to learn large disparities. Finally, we demonstrate that our alignment architecture outperforms a state-of-the art optical flow network on the image warping task when both systems are trained in an identical manner.Peer Reviewe

Multi-Level Toolset for Steering Urban Green Infrastructure to Support the Development of Climate-Proofed Cities

Adapting spatial development to the challenges of climate change is a major task facing cities. In particular, urban heat islands caused by increasing average temperatures and urban growth are a challenge for cities. The use of climate simulations to assess current and future urban heat stress is a helpful approach for supporting this transition. In particular, green and blue infrastructure helps to reduce the urban heat island effect. These cooling effects can be analysed using simulations. However, a central challenge is that urban adaptation to heat needs to be implemented consistently at different planning levels. A second major challenge in adaption is identifying the amount of urban green infrastructure required in order to achieve a specific cooling benefit and establishing this by means of planning instruments. This article presents two case studies in the city of Vienna to demonstrate how climate simulation tools can be used across different planning levels if they are standardized. When combined with a green and open space factor as a steering instrument, the necessary amount of greening for subsequent planning processes can be secured. The result is a multi-scale toolset consisting of three climate simulation models and a green and open space factor, coordinated, and standardised for use at different levels of planning